Job Description

Compensation & Benefits:

• $140K-$215K (20% bonus) Exact compensation may vary based on several factors, including skills, experience, and education.
• Benefit packages for this role will start on the 1st day of employment and include medical, dental, and vision insurance, as well as HSA, FSA, and DCFSA account options, and 401k retirement account access with employer matching. Employees in this role are also entitled to paid sick leave and/or other paid time off as provided by applicable law.

Purpose: The Discovery Technologies & Molecular Pharmacology (DTMP) team within Therapeutics Discovery contributes to the progression of drug discovery projects from target identification to clinical development. Join our team! We’re looking for a talented scientist with an immunology background, deep expertise in disease biology and cellular pharmacology, and a passion for finding innovative therapeutics to treat diseases with high unmet medical need.

Key Responsibilities:

• Lead development of innovative cell-based assays for immunology-focused projects to identify and evaluate targets, and to progress hits and lead molecules.
• Act as a key liaison between DTMP and program teams, driving project strategy and execution, in partnership with cross-functional colleagues.
• Lead efforts to combine translational and mechanistic assays with biosignature approaches and novel AI/ML methods to reveal new biology and pharmacology.
• Manage and mentor lab scientists and contribute to the cellular and mechanistic pharmacology portfolio.
• Analyze and present data at program team meetings, in-house seminars, leadership meetings and external scientific conferences, and publish research in high-quality journals.

Qualifications

• Minimum of Ph. D. in Immunology, cell biology or equivalent with post-doctoral experience and a minimum of 10 years of experience developing and applying novel cellular assays in a pharmaceutical industry/biotech setting, is required.

Required Experience and Skills:

• Proven track record in managing immunology-focused drug discovery programs across diverse modalities, in an industry setting.
• Deep expertise and proven accomplishments in de novo immunology cellular pharmacology assay development, complex immune cellular models and high-throughput technology platforms.
• Experience with generating and culturing translationally relevant cell models such as iPSC-derived cells, primary cells, and/or co-cultures.
• Expertise collecting and analyzing data using high dimensional approaches such as high content imaging, flow cytometry and/or RNAseq.
• Strong experience as a leader, problem solver and team collaborator able to facilitate understanding between biologists, chemists, and data scientists.
• A demonstrated ability to apply novel approaches to address complex biology questions, as evidenced through strong peer-reviewed publications.
• Excellent written communication, verbal communication, and oral presentation skills.
• Demonstrated influence, negotiation, and conflict resolution skills.

Preferred:

• Expertise in assay automation.
• Proficiency with CAS/CRISPR, lentivirus and/or RNAi approaches.
• Expertise developing assays in advanced 3D cell models.
• Expertise in neuroscience and/or oncology therapeutic areas.
• Experience working with and/or guiding external collaborators in industry or academia.

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